Case Report: Severe non-immune mediated haemolytic anaemia associated with acute hepatitis B and E co-infection in a patient with normal G6PD levels [version 1; referees: 1 not approved]
نویسندگان
چکیده
Severe non-immune mediated haemolytic anaemia (HA) rarely occurs in acute viral hepatitis, unless patients have underlying red cell enzyme abnormalities or pre-existing liver disease. We report such a case and provide a summary of other available cases to date. Overall, young and fit patients suffering from acute viral hepatitis seem to be affected. Several viral subtypes have been associated, although we report the first hepatitis B and E co-infection case. It seems to occur when patients are recovering from hepatitis and the disease course is variable. The degree of anaemia is always severe, and is inevitably associated with increased morbidity and mortality. Several theories exist with regard to its aetiology, including the disruption of erythrocyte metabolism. Although its optimal treatment strategies remain unclear, some evidence suggests a possible role for steroid therapy. Michael Wang ( ) Corresponding author: [email protected] Wang M, Yap F and Joynt G. How to cite this article: Case Report: Severe non-immune mediated haemolytic anaemia associated with 2015, acute hepatitis B and E co-infection in a patient with normal G6PD levels [version 1; referees: 1 not approved] F1000Research 4 :1002 (doi: ) 10.12688/f1000research.7086.1 © 2015 Wang M . This is an open access article distributed under the terms of the , which Copyright: et al Creative Commons Attribution Licence permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The author(s) declared that no grants were involved in supporting this work. Grant information: Competing interests: No competing interests were disclosed. 06 Oct 2015, :1002 (doi: ) First published: 4 10.12688/f1000research.7086.1 1 2 1 2 Referee Status: Invited Referees version 1 published 06 Oct 2015 1 report 06 Oct 2015, :1002 (doi: ) First published: 4 10.12688/f1000research.7086.1 06 Oct 2015, :1002 (doi: ) Latest published: 4 10.12688/f1000research.7086.1 v1 Page 1 of 6 F1000Research 2015, 4:1002 Last updated: 25 DEC 2016
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